Журнал «Медицина неотложных состояний» 4 (67) 2015
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Effect of Infusion Therapy on Redox-Balance of Oxidant-Antioxidant Systems of Lung Tissues in Severe Concomitant Injury in an Experiment
Авторы: Roshchin H.H., Kryliuk V.O., Kuzmin V.Yu. - Department of Emergency Medicine of National Medical Academy of Postgraduate Education named after P.L. Shupyk, Kyiv; Hudyma A.A. - State Higher Educational Institution «Ternopil State Medical University named after I.Ya. Horbachevskyi of Ministry of Healthcare of Ukraine», Ternopil; Ivanov V.I., Maksymenko M.A., Penkalskyi O.O. - State Institution «Ukrainian Scientific and Practical Center of Emergency Care and Disaster Medicine of Ministry of Healthcare of Ukraine», Kyiv, Ukraine
Рубрики: Медицина неотложных состояний
Разделы: Справочник специалиста
Версия для печати
severe concomitant injury, malondialdehyde, diene conjugates, catalase, superoxide dismutase, oxidation index, experiment.
Summary. Against the background of experimental severe concomitant injury, there has been studied the effect of infusion therapy on cytotoxicity of prooxidant systems (malondialdehyde and diene conjugates) and the activity of antioxidant level of enzymes (superoxide dismutase and catalase) in the lung tissues of experimental animals. It has been established that in the context of early infusion therapy, already within 6 hours of the traumatic process, there occurs a decrease in the activity of these indicators, as well as the redox-balance of oxidant-antioxidant systems in the lung tissues. The best survival rates during 24 hours were in animals which were administered a drug of combined infusion therapy (HAES-LX 5%) based on 5% hydroxiethyl starch 130/0.4, 5% xylitol, 1.5% sodium lactate and balanced electrolyte solution.
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